Patient Information Leaflet. Package leaflet: Information for the patient. Byetta 5 micrograms solution for injection in pre-filled pen. Byetta 10 micrograms solution . Learn about BYETTA, the BYETTA Pen. in patients with prior severe hypersensitivity reactions to exenatide or to any of the product components. PRODUCT MONOGRAPH. BYETTA® exenatide injection. µg/mL. mL prefilled pen (60 doses of 5 µg/dose) and. mL prefilled pen.
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Official BYETTA® (exenatide) injection Healthcare Professional Website
Adequate blood glucose monitoring should be continued and followed. Rotate administration sites with each injection to prevent lipodystrophy. Patients treated with pasireotide may experience either hypoglycemia or hyperglycemia.
Indapamide pacjage decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Stop taking BYETTA and call your healthcare provider right away if you have pain in your stomach area abdomen that is severe, and will not go away, occurs with or without vomiting or is felt going from your abdomen through to your back.
Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate: Other oral hypoglycemics may also be considered as possible alternatives in some patients. Do not store the pen with the needle on, as the medication may leak inserh or air bubbles may form in the cartridge. According to OBRA, the use of antidiabetic medications should include ppackage e. In addition, diuretics reduce the risk of stroke and cardiovascular disease in patients with diabetes.
Clonidine does not appear to impair recovery from hypoglycemia, and has not been found to impair glucose tolerance in diabetic patients. Once the needle is inserted, press the injection button until you hear a “click” and then hold the button for 15 additional seconds to deliver the full dose. Both first- and second-phase insulin secretion improved significantly over placebo in patients with type 2 diabetes. For lixisenatide, the manufacturer recommends taking the OC 1 hour before injection or 11 hours after injection to reduce the effect on absorption.
Moderate Monitor patients receiving octreotide concomitantly with insulin or other antidiabetic agents for changes in glycemic control and adjust doses of these imsert accordingly. Your email has packagge sent. Inject subcutaneously into the thigh, abdomen, or upper arm. Patients on antidiabetic agents should be monitored for the need for dosage adjustments during the use of pentamidine.
It appears that the effects of thiazide diuretics on glycemic control are dose-related and low doses can be instituted without deleterious effects on glycemic control. In severe hypoglycemia, intravenous dextrose or glucagon injections may be needed.
Because of the potential for clinically significant adverse reactions from exenatide in breast-fed infants, caution should be exercised, and a decision should be made whether to discontinue nursing or discontinue the drug, taking into account these potential risks against the glycemic benefits to the lactating woman.
While beta-blockers may have negative effects on glycemic control, they reduce the risk of indert disease and stroke in patients with diabetes and inssert use should not be avoided in patients with compelling indications for beta-blocker therapy when no other contraindications packafe present.
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Since beta blockers inhibit the release of catecholamines, these medications may hide symptoms of hypoglycemia such as tremor, tachycardia, and blood pressure changes. In animal developmental studies rabbits, miceexenatide caused cleft palate, irregular skeletal ossification, and an increased number of neonatal deaths.
Exenatide acutely improves glycemic control by reducing fasting and postprandial glucose concentrations in patients with type 2 diabetes. Furthermore, tacrolimus has been implicated in causing insulin-dependent diabetes mellitus in patients after renal transplantation. Administer twice daily, within the minute time period prior to the morning and evening meals.
Use with caution in patients with renal transplantation or when initiating or escalating the dose in patients with moderate renal failure. Send the page ” ” to a friend, relative, colleague or yourself.
Symptoms of a severe allergic reaction include severe rash or itching, swelling of your face, lips, and throat that may cause difficulty breathing or swallowing, feeling faint or dizzy and very rapid heartbeat. The risk of hypoglycemia is increased when exenatide is used in combination with insulin secretagogues e. Therefore, careful monitoring of blood glucose is recommended when quinolones and antidiabetic agents are co-administered.
No placebo-treated patients withdrew due to nausea or vomiting. Initially, surface-bound exenatide is released resulting in an initial peak around week 2. Changes in glucose tolerance occur more commonly in patients receiving 50 mcg or more of ethinyl estradiol or equivalent per day in combined oral contraceptives COCswhich are not commonly used in practice since the marketing of lower dose COCs, patches, injections and rings.
Staying Active Learn how regular physical activity can help you manage type 2 diabetes. Minor Loop diuretics, such as bumetanide, furosemide, and torsemide, may cause hyperglycemia and glycosuria in patients with diabetes mellitus, probably due to diuretic-induced hypokalemia.
The Cmax byettz increased less than proportionally over the same range. If a patient chooses to ingest alcohol, they should monitor their blood glucose frequently. Patients should be counseled on the risk byettx symptoms of thyroid tumors e. Adjust treatment with antidiabetic agents as clinically indicated. Administer at any time of day, with or without meals.
Both hyperglycemia and hypoglycemia have been described in patients treated with acetazolamide. This site is intended for US Consumers. Hyperglycemia has pzckage reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas.
Higher incidences were noted in males above packagge in all treated groups at 2 times or more clinical exposure. Exenatide does not increase insulin activity in nondiabetics. After acute overdose, aspirin can cause either hypo- or hyperglycemia. Major Careful monitoring of blood glucose is recommended when hydroxychloroquine and antidiabetic agents, including the incretin mimetics, are coadministered.
Major Careful monitoring of blood glucose is recommended when chloroquine and antidiabetic agents, including the incretin mimetics, are coadministered.
Should not be used in patients with severe inert impairment or end-stage renal disease. Based on postmarketing data BYETTA has been associated with acute packxge, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis. Alternatively, administer insery the 2 main meals of the day, approximately 6 hours or more apart. Exenatide is not a substitute for insulin in patients who require insulin.
The concurrent use of exenatide with prandial insulin has not been studied. Your risk for getting low blood sugar hypoglycemia is higher if you take BYETTA with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Moderate Monitor blood glucose levels regularly in patients with diabetes, especially when pasireotide treatment is initiated or when the dose is altered.